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Crizotinib-d5

CAS No. : 1395950-84-1

Biological Activity：Crizotinib-d5 (PF-02341066-d5) is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition^[2]^[3].

Research Area：Cancer

Targets：Autophagy|c-Met/HGFR|ROS Kinase|Anaplastic lymphoma kinase (ALK)

Related Small Molecules:AMG-208;ALK-IN-9;D6808;MET kinase-IN-2;c-Met-IN-9;Tyrosine kinase-IN-4;KRCA-0008;Savolitinib;Foretinib;Alectinib-d8;PF-04217903 phenolsulfonate;Taletrectinib;MS4078;MK-2461;TL13-22;XL092;SAR125844;MK-8033 hydrochloride;NVP-TAE 684;GGTI-2154 hydrochloride;MitoPQ;ALK5-IN-30;TL13-112;ALK-IN-22;BPI-9016M;Ficlatuzumab;Alectinib

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