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CLP257

CAS No. : 1181081-71-9

Biological Activity：CLP257 is a selective K⁺-Cl⁻ cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl⁻ transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally^[2].

Research Area：Neurological Disease

Targets：Potassium Channel

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:Kv3 modulator 2;Brompheniramine-d6 maleate;Pinacidil;AMP-PNP tetralithium;IK1 inhibitor PA-6;VU590;Domiphen bromide;Mesoridazine benzenesulfonate;Tetrandrine;20(S)-Ginsenoside Rg3;(S)-(+)-Modafinic acid-d5;Ketanserin;PE 22-28;Ifenprodil tartrate;Brompheniramine maleate;L-Palmitoylcarnitine-d3 hydrochloride;Phe-Met-Arg-Phe amide trifluoroacetate;Mitiglinide;Flupirtine-d4 hydrochloride;Kaliotoxin (1-37);Tifenazoxide;Agitoxin-2 TFA

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