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CHMFL-PI3KD-317

CAS No. : 2244992-76-3

Biological Activity：CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC₅₀, 62.6 nM), PI3Kβ (IC₅₀, 284 nM), PI3Kγ (IC₅₀, 202.7 nM), PIK3C2A (IC₅₀, >10000 nM), PIK3C2B (IC₅₀, 882.3 nM), VPS34 (IC₅₀, 1801.7 nM), PI4KIIIA (IC₅₀, 574.1 nM) and PI4KIIIB (IC₅₀, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC₅₀ of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.

Research Area：Cancer

Targets：PI3K

Related Small Molecules:Umbralisib hydrochloride;Topoisomerase I/II inhibitor 3;Rigosertib sodium;Tenalisib R Enantiomer;PI3kδ inhibitor 1;PI3K/VEGFR2-IN-1;1,3-Dicaffeoylquinic acid;PI3Kδ-IN-1;PI-103-d8;PI3Kα-IN-8;PI-103 Hydrochloride;IC-87114;PI3K/mTOR Inhibitor-6;PI3K-IN-10;SF2523;PI3K-IN-29;PI3K/mTOR Inhibitor-1;PI3K-IN-26;GSK-F1;Serabelisib;Amdizalisib;Glaucocalyxin A;PI3K/AKT-IN-2;PIK-294;CAL-130 Hydrochloride;YS-49;hSMG-1 inhibitor 11e

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