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Calcimycin hemimagnesium

CAS No. : 72124-77-7

Biological Activity：Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis^[2]^[3]^[4].

Research Area：Cancer|Infection

Targets：Fungal|Autophagy|Bacterial|Apoptosis

Related Small Molecules:Antifungal agent 20;Physalin A;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Debneyol;Leucomycin;Isouvaretin;BJE6-106;Dinaciclib;Haloprogin;Antibacterial agent 99

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