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BRD9876

CAS No. : 32703-82-5

Biological Activity：BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research^[2]^[3]^[4].

Research Area：Cancer

Targets：Microtubule/Tubulin|Kinesin

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Cytoskeleton Compound Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:Tirbanibulin dihydrochloride;Tilavonemab;Tau tracer 1;Dolastatin 10;Ceratamine A;Batabulin sodium;OXi8007;Antitumor agent-68;Dictyostatin;Tubulin inhibitor 6;Oryzalin;Tubulin inhibitor 25;Fmoc-MMAE;Taltobulin;Tubulin inhibitor 16;Epothilone B;TN-16;Maytansinol;Kif15-IN-1;VcMMAE;EMD534085;Mc-MMAE;SS28;Tubulysin H;Fosbretabulin disodium

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