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ATR-IN-20

Biological Activity：ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC₅₀ of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC₅₀ of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects.

Research Area：Cancer

Targets：mTOR|ATM/ATR

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;ATR-IN-16;ATR-IN-4;Cyclovirobuxine D;WYE-354;L-Leucine-1-13C,15N;CGK733;PI-103-d8;Palomid 529;PI-103 Hydrochloride;Ceralasertib;RMC-5552;OXA-01;L-Leucine-15N;PI3K/mTOR Inhibitor-6;KU 59403;PI3K/mTOR Inhibitor-1;ATM Inhibitor-1;HDACs/mTOR Inhibitor 1;Chromeceptin;hSMG-1 inhibitor 11e;PI3Kα/mTOR-IN-1;ATR-IN-5;ATR inhibitor 1;VE-821;RapaLink-1;Torin 1;Dihydromyricetin;KU-55933

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