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ATR-IN-12

Biological Activity：ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with an IC₅₀ value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level of ATR and its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targeting ATR kinase.

Research Area：Cancer

Targets：ATM/ATR

Related Small Molecules:ATR-IN-16;ATR-IN-4;CGK733;Ceralasertib;KU 59403;ATM Inhibitor-1;ATR-IN-5;ATR inhibitor 1;VE-821;KU-55933;Garcinone C;SKLB-197;ATR-IN-18;AZD0156;CP-466722;Mirin;ATR-IN-13;Antitumor agent-28;ATR-IN-11;ATR-IN-8;AZ31;ATR-IN-20;ATM Inhibitor-2;Elimusertib;Ro 90-7501;Gartisertib;ATR-IN-7;ATR-IN-17;KU-60019

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