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Anemarsaponin B

CAS No. : 139051-27-7

Biological Activity：Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

Research Area：Inflammation/Immunology

Targets：MEK|NF-κB|NO Synthase|COX

Related Small Molecules:Carboxy-PTIO potassium;Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;Avutometinib;Valeriandoid F;Icariside F2;IKKγ NBD Inhibitory Peptide TFA;Ciwujianoside C3;Mangiferin;Antioxidant agent-5;ALPK1-IN-1;NOS-IN-3;Regaloside A;IMD-ferulic;SN52;Ampyrone;COX-2-IN-24;5-Aminosalicylic Acid-D3 hydrochloride;Cobimetinib racemate;Ginsenoside Rg1;Echinulin;Aminopicoline;Licochalcone D;Zaltoprofen-d7;QNZ;trans-Isoferulic acid;BIZ 114;NF-κΒ activator 1

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