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AG-494

CAS No. : 133550-35-3

Biological Activity：AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC₅₀=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC₅₀s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis^[2]^[3].

Research Area：Cancer

Targets：EGFR|CDK

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Differentiation Inducing Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:DB0614;NSC81111;Dinaciclib;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;SNS-032;CC-671;(E/Z)-Zotiraciclib;Osimertinib-13C,d3;CDK1-IN-4;CCT-251921;BS-181;EGFR-IN-5;FGFR2-IN-3;Samuraciclib hydrochloride hydrate;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;FLT3/CDK4-IN-1;Genistein;Epertinib hydrochloride;GFB-12811;GSK 3 Inhibitor IX;Eciruciclib;UNC-CA359;CDK-IN-6

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