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AFM-30a
CAS No. : 2095107-57-4
Biological Activity：AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
Research Area：Cancer|Inflammation/Immunology
Targets：Protein Arginine Deiminase
Related Small Molecules:BMS-P5;GSK484 hydrochloride;BB-Cl-Amidine;D-Cl-amidine;GSK121;Cl-amidine TFA;PAD2-IN-1;Streptonigrin;PAD-IN-2;GSK199;Acefylline;GSK106
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