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MAO-B-IN-1

CAS No. : 2834758-29-9

Biological Activity：AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC₅₀s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ₁ and σ₂ receptors with K_i values of 42.8 nM (human σ₁ receptor) and 191 nM (rat σ₂ receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research.

Research Area：Neurological Disease

Targets：Monoamine Oxidase|Cholinesterase (ChE)

Related Small Molecules:PXS-4728A;Piperilate;BuChE-IN-5;Hypericin;AChE/BChE-IN-10;Simtuzumab;SSAO inhibitor-1;Timosaponin AIII;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11;5-HT6R/MAO-B modulator 1;Heliosupine;(-)-Cyclopenin;Glicoricone;Leptomerine

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