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VHL Ligand 8
Biological Activity：VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM.
Research Area：Cancer
Targets：Ligands for E3 Ligase
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library;Ubiquitination Compound Library;Anti-Prostate Cancer Compound Library;E3 Ligase Ligand Library;
Related Small Molecules:(S,R,S)-AHPC TFA;CRBN modulator-1;cIAP1 ligand 4;(S,R,S)-AHPC-Me;cIAP1 ligand 2;E3 ligase Ligand 23;VH032;BC-1215;VH032-cyclopropane-F;KB02-COOH;N-Boc-SBP-0636457-OH;SJPYT-195;TD-106;CC-885;VH032-OH
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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