For research use only. We do not sell to patients.

VH285-PEG4-C4-Cl

CAS No. : 1799506-07-2

Biological Activity：VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC₅₀ of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC₅₀ of 0.54 μM.

Targets：E3 Ligase Ligand-Linker Conjugates

Related Small Molecules:cIAP1 Ligand-Linker Conjugates 6 hydrochloride;(S,R,S)-AHPC-Me-C10-NH2;cIAP1 Ligand-Linker Conjugates 2;Glutarimide-Isoindolinone-NH-PEG3-COOH;cIAP1 Ligand-Linker Conjugates 4;(S,R,S)-AHPC-Me-C7 ester;(S,R,S)-AHPC-C2-PEG4-N3;cIAP1 Ligand-Linker Conjugates 5;cIAP1 Ligand-Linker Conjugates 7;cIAP1 Ligand-Linker Conjugates 16;(S,R,S)-AHPC-C8-NH2 hydrochloride;cIAP1 Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG4-NH2;VHL Ligand-Linker Conjugates 15;VH032-PEG3-acetylene;(S,R,S)-AHPC-PEG2-NH2 dihydrochloride;VH032-PEG5-C6-Cl;(S,R,S)-AHPC-Me-C5-COOH

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

About Us:

• MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
• Structurally and synthetically diverse biologically active compounds；
•  roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
• We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
• Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

• Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.