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Vardenafil hydrochloride

CAS No. : 224785-91-5

Biological Activity：Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels^[2]. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes^[1]-[6].

Research Area：Endocrinology|Metabolic Disease|Inflammation/Immunology

Targets：Phosphodiesterase (PDE)|Endogenous Metabolite

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Anti-diabetic Compound Library;Endocrinology Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;EMA-Approved Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;Senazodan hydrochloride;(E/Z)-HA155;2-Mercaptobenzothiazole;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Enpp/Carbonic anhydrase-IN-1;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Pregnenolone monosulfate sodium;ATX inhibitor 22;25-Hydroxycholesterol-d6;Carbazeran citrate;Pyrroloquinoline quinone;Roridin L2;NAPQI

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