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Valproic acid
CAS No. : 99-66-1
Biological Activity：Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[2][3][4][5][6][7].
Research Area：Cancer|Infection|Metabolic Disease|Neurological Disease
Targets：Notch|Autophagy|HDAC|HIV|Mitophagy|Endogenous Metabolite|Apoptosis
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound Library Plus;
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