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Toyocamycin
CAS No. : 606-58-6
Biological Activity：Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM[2][3].
Research Area：Cancer|Infection
Targets：Fungal|IRE1|CDK|Antibiotic|Apoptosis
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Natural Product Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Antifungal Compound Library;Endoplasmic Reticulum Stress Compound Library;Antibiotics Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Microbial Metabolite Library;Anti-Cancer Natural Product Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Antifungal agent 20;Physalin A;Bomedemstat ditosylate;Sandramycin;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Debneyol;Leucomycin;BJE6-106;Dinaciclib;Haloprogin;Ecteinascidin 770;MDM2-p53-IN-15;Vidarabine monohydrate;Nafcillin
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