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Tomivosertib

CAS No. : 1849590-01-7

Biological Activity：Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC₅₀s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC₅₀=2-16 nM) in tumor cell lines. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance^[2].

Research Area：Cancer

Targets：MNK|PD-1/PD-L1

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Small Molecule Immuno-Oncology Compound Library;Drug Repurposing Compound Library;Oxygen Sensing Compound Library;Orally Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Protein-protein Interaction Inhibitor Library;Anti-Prostate Cancer Compound Library;

Related Small Molecules:PD-1/PD-L1-IN-15;PD-1/PD-L1-IN 5 TFA;PD-1/PD-L1-IN-25;PD-1/PD-L1-IN-18;PD-1/PD-L1-IN-22;Toripalimab;PD-1/PD-L1-IN-23;PD-1-IN-24;Evixapodlin;PD-1/PD-L1-IN-28;Onvatilimab;MNK1/2-IN-5;BMS-1001 hydrochloride;PD-1-IN-20;AUNP-12;BMSpep-57 hydrochloride;PD-1-IN-17;QL-X-138;Cercosporamide;Anti-Mouse PD-L1 Antibody;ARB-272572;INCB086550;N2S2-CBMBC;Sintilimab;PD-1/PD-L1-IN 3;DS12881479;PD-1/PD-L1-IN-27;PD-1/PD-L1-IN-13;D18

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