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TM-1
CAS No. : 921099-13-0
Biological Activity：TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.
Research Area：Cancer
Targets：PDHK
Related Screening Libraries:Natural Product-like Compound Library;Bioactive Compound Library Plus;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Glycolysis Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;
Related Small Molecules:AZD7545;M77976;PDK4-IN-1;PDHK-IN-5;KPLH1130;Dicoumarol-d8;Sodium dichloroacetate;Leelamine;PS10;PDHK-IN-3;VER-246608;PDHK-IN-4;JX06;Dicoumarol
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