For research use only. We do not sell to patients.
T0901317
CAS No. : 293754-55-9
Biological Activity：T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM[2]. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice[4][5].
Research Area：Cancer|Metabolic Disease|Cardiovascular Disease
Targets：LXR|FXR|ROR|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Chemical Probe Library;Transcription Factor-Targeted Library;Lipid Metabolism Compound Library ;Human Metabolite Library;Nuclear Receptor Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;RORγt inhibitor 1;GNE-6468;SR3335;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;DY268;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;RORγt inverse agonist 30;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;GNE-0946;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
