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Sograzepide-d3

Biological Activity：Sograzepide-d3 (Netazepide-d3) is the deuterium labeled Sograzepide. Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC₅₀ of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with K_i values of 0.068, 0.62 and 0.19 nM, respectively^[2].

Research Area：Metabolic Disease|Endocrinology

Targets：Cholecystokinin Receptor

Related Small Molecules:Loxiglumide;Gastrin I, human;(Rac)-Sograzepide;Nastorazepide;Proglumide;Lorglumide sodium salt;LY288513;Tarazepide;L-365260 hemihydrate;Mini Gastrin I, human TFA;CCK-B Receptor Antagonist 2;CI-988;Gastrin I, rat;JNJ-26070109;CHEMBL333994;Gastrin/CCK antagonist 1;Dexloxiglumide;N-acetyl CCK-(26-30) amide;Tetragastrin;SR 146131;Lintitript;A71623;GI 181771;Devazepide

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