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Simeprevir

CAS No. : 923604-59-5

Biological Activity：Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses^[4].

Research Area：Infection

Targets：HCV|DNA/RNA Synthesis|HCV Protease|SARS-CoV

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Antiviral Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Macrocyclic Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Hepatitis C Virus Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;EMA-Approved Drug Library;

Related Small Molecules:Ametantrone;HCV-IN-30;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;NS5A-IN-1;HCV-IN-38;P1788;SARS-CoV-2-IN-33;Thymidine-13C5,15N;NSC 617145;GRL-0496;116-9e;Sennidin A;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;HCV-IN-31;6-Thio-2′-Deoxyguanosine;Radalbuvir;Antitumor agent-74;Grazoprevir potassium salt

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