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SI-109
CAS No. : 2429877-30-3
Biological Activity：SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.
Research Area：Cancer
Targets：Ligands for Target Protein for PROTAC|STAT
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:Cirsilineol;Ochromycinone;C188-9;STAT3-IN-10;C188;Niclosamide monohydrate;STAT3-IN-1;STAT3 degrader-1;BI-4464;PROTAC BRD4 ligand-2;PM-81I;PROTAC BRD9-binding moiety 1 hydrochloride;PROTAC IRAK4 ligand-1;Apcin-A;Morusin;Nifuroxazide-13C6;AS1810722;α7 nAchR-JAK2-STAT3 agonist 1;HP590;Eupalinolide K;STAT3-IN-11;Ipatasertib-NH2 dihydrochloride;(R)-Reticuline-d3;JAK-IN-23;UC-514321
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