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SHR902275

CAS No. : 2695506-82-0

Biological Activity：SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC₅₀s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAF^wt, and bRAF^V600E, respectively. SHR902275 shows cell growth inhibition with GI₅₀s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.

Research Area：Cancer

Targets：Raf

Related Small Molecules:Avutometinib;AZ 628;Everafenib;L-779450;Raf inhibitor 1;PLX-4720;RRD-251;B-Raf IN 8;TAK-632;Encorafenib;RAF mutant-IN-1;AD80;CCT241161;PLX7904;RAF-IN-1;EGFR/BRAFV600E-IN-1;MCP110;GDC-0879;B-Raf IN 1;R18;Rineterkib

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