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SB-334867
CAS No. : 249889-64-3
Biological Activity：SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo[2][3].
Research Area：Neurological Disease|Endocrinology
Targets：Orexin Receptor (OX Receptor)
Related Small Molecules:MK-3697;JNJ-54717793;TCS-OX2-29;IPSU;Seltorexant hydrochloride;Orexin B, rat, mouse;SB-649868;Orexin A (human, rat, mouse) (acetate);SB-408124 Hydrochloride;OX2R-IN-1;EMPA;Orexin B, human;SB-334867 free base;MK-1064;Almorexant-13C,d3;YNT-185 dihydrochloride;Orexin 2 Receptor Agonist;[Ala11,D-Leu15]-Orexin B(human);Suntinorexton;Almorexant;SB-674042;Filorexant;Orexin receptor antagonist 4;OXA(17-33) TFA;Lemborexant;Danavorexton
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