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Rifalazil
CAS No. : 129791-92-0
Biological Activity：Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
Research Area：Infection|Inflammation/Immunology
Targets：DNA/RNA Synthesis|Bacterial
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Macrocyclic Compound Library;Antibacterial Compound Library;Rare Diseases Drug Library;
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