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Resatorvid
CAS No. : 243984-11-4
Biological Activity：Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[2].
Research Area：Inflammation/Immunology|Cancer
Targets：TNF Receptor|Autophagy|Interleukin Related|Toll-like Receptor (TLR)
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Autophagy Compound Library;Small Molecule Immuno-Oncology Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Rare Diseases Drug Library;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:C29;Akt/NF-κB/JNK-IN-1;AX-024;TMX-201;Ginsenoside F3;Perakizumab;RS 09;ODN 20844;PNRI-299;TLR7/8-IN-1;TLR8 agonist 5;QNZ;CTX-471;Ac-YVAD-CHO;Sinulatumolin E;Deucravacitinib;Sulfo-ara-F-NMN;TLR7/8 antagonist 1;Gardiquimod;Epobis;PF-4878691;Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH;Mulberroside A;Pepinh-TRIF TFA;Afimetoran;Sinulatumolin D
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