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(R)-JNJ-31020028
CAS No. : 1094873-17-2
Biological Activity：(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects[2].
Research Area：Neurological Disease
Targets：Neuropeptide Y Receptor
Related Small Molecules:[D-Trp34]-Neuropeptide Y TFA;Pancreatic Polypeptide, human;Peptide YY (PYY), human;JNJ-5207787;[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA;GR231118 TFA;Neuropeptide Y (human);RF9 hydrochloride;M1145;Galanin Receptor Ligand M35 TFA;Neuropeptide Y (3-36) (porcine);BMS-193885;CART (55-76), rat;Galantide;RFRP-3(human) TFA;BIBO3304 TFA;Neuropeptide SF(mouse,rat);Galanin (1-16), mouse, porcine, rat;FR252384;Galnon;[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide;CART (1-39), Human, Rat;Neuropeptide Y (13-36), amide, human;Neuropeptide S(Rat);Neuropeptide Y (22-36);Lu AA33810;Neuropeptide Y (3-36) (human, rat)
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