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PZ-2891
CAS No. : 2170608-82-7
Biological Activity：PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
Research Area：Neurological Disease
Targets：Others
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;CNS-Penetrant Compound Library;Orally Active Compound Library;Chemical Probe Library;Targeted Diversity Library;
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