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PS315
CAS No. : 1221964-50-6
Biological Activity:PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity.
Research Area:Cancer
Targets:PKC
Related Small Molecules:[Ala107]MBP(104-118) TFA;BJE6-106;Myelin Basic Protein;Staurosporine;PKC-iota inhibitor 1;Hypericin;Malantide;PKCiota-IN-2 formic;PF-4950834;C8 Dihydroceramide;SC-9;DL-erythro-Dihydrosphingosine;Safingol;ZIP;Psychosine-d5;TPPB;Enzastaurin;Protein Kinase C (19-31);Protein kinase inhibitor H-7 dihydrochloride;Teleocidin A1;Ro 31-8220;[Ser25] Protein Kinase C (19-31);CGP60474
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