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PROTAC PD-1/PD-L1 degrader-1
CAS No. : 2447066-37-5
Biological Activity:PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.
Research Area:Inflammation/Immunology
Targets:PD-1/PD-L1|PROTACs
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;PD-1/PD-L1-IN-15;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;PD-1/PD-L1-IN 5 TFA;MS98;JPS014;PROTAC PARP1 degrader;MD-224;PD-1/PD-L1-IN-25;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;RIP2 Kinase Inhibitor 4;PROTAC EGFR degrader 7;SJ995973;CC-885-CH2-PEG1-NH-CH3;dFKBP-1;MI-389;BSJ-4-116;MS4078;PD-1/PD-L1-IN-18;PZ703b;DP-C-4
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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