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PLK1/BRD4-IN-1
CAS No. : 2412707-81-2
Biological Activity：PLK1/BRD4-IN-1 (9b) is an orally active dual PLK1 and BRD4 inhibitor with IC50 values of 22 nM and 109 nM against PLK1 and BRD4, respectively. PLK1/BRD4-IN-1 induces cell cycle arrest and apoptosis, downregulates the transcription of several proliferation-related oncogenes, and exhibits favorable in vivo antitumor activity.
Research Area：Cancer
Targets：Epigenetic Reader Domain|Polo-like Kinase (PLK)|Apoptosis
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;RVX-297;Lobetyolin;BRD4 Inhibitor-19;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;TAK-960;ZLDI-8;Topoisomerase I/II inhibitor 3;UNC6349 (Ket2);Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9
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