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Peretinoin

CAS No. : 81485-25-8

Biological Activity：Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression^[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM^[3].

Research Area：Cancer|Infection

Targets：HCV|Autophagy|RAR/RXR|SphK

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Antiviral Compound Library;Autophagy Compound Library;Drug Repurposing Compound Library;Lipid Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Hepatitis C Virus Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Protein-protein Interaction Inhibitor Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Nuclear Receptor Compound Library;

Related Small Molecules:HCV-IN-30;AGN 193109-d7;HCV-IN-38;Sennidin A;Retinoic acid;HCV-IN-31;Radalbuvir;Grazoprevir potassium salt;FGI-106 tetrahydrochloride;BMS-986144;Oenothein B;Triton X-45(n=4);Mecarbinate;Artemisinin-d3;TTP-8307;HCV-IN-34;Miravirsen;Ciluprevir

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