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Osilodrostat

CAS No. : 928134-65-0

Biological Activity：Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC₅₀ value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC₅₀ values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS)^[2][3].

Research Area：Cancer|Inflammation/Immunology

Targets：Mineralocorticoid Receptor

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Cancer Metabolism Compound Library;Rare Diseases Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Nuclear Receptor Compound Library;

Related Small Molecules:Desoxycorticosterone pivalate-d8;Canrenone-d6;Oxprenoate potassium;(S)-Baxdrostat;Canrenone-d4;18-Oxocortisol;Desoxycorticosterone pivalate;Vamorolone;Dicirenone;Balcinrenone;Lorundrostat;Esaxerenone;Deoxycorticosterone acetate;Canrenoate potassium;Ocedurenone;Apararenone;PF-3882845;Finerenone

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