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Nisoldipine
CAS No. : 63675-72-9
Biological Activity：Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
IC50 value: 10 nM
Target: L-type Cav1.2
Nisoldipine is a potent blocker of L-type calcium channels. Nisoldipine binds directly to inactive calcium channels stabilizing their inactive conformation Similar to other DHP CCBs. Nisoldipine displays selectivity for arterial smooth muscle cells due to great number of inactive channels and the α1 subunit of the channel. Nisoldipine is about 30 times less selective for delayed-rectifier K+ channels than for L-type Ca2+ channels, which inhibits IKr (rapidly activating delayed-rectifier K+ current) with IC50 of 23 μM, and IKs (slowly activating delayed-rectifier K+ current)with IC50 of 40 μM in guinea-pig ventricular myocytes. Nisoldipine also displays antioxidant potency with IC50 of 28.2 μM both before and after the addition of active oxygen.
Research Area：Cardiovascular Disease
Targets：Calcium Channel|Reactive Oxygen Species
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound Library Plus;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose heptahydrochloride;Benidipine hydrochloride;CaV1.3 antagonist-1;14-Deoxyandrographolide;N-Acetyl-D-cysteine;Topoisomerase I/II inhibitor 3;CYPMPO;Antioxidant agent-5;(Rac)-MEM 1003;ROS-ERS inducer 1;Glaucine;Efonidipine hydrochloride monoethanolate;Glucosamine-13C hydrochloride;L-Ascorbic acid sodium salt;Brompheniramine-d6 maleate;D-Isofloridoside;MRS 1523;L-Carnitine-d3 hydrochloride;Nilvadipine;Licochalcone D;Lercanidipine;Euparin;RH-EDA;1,3-Dicaffeoylquinic acid;CP-060
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