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NIC-0102
CAS No. : 2806031-94-5
Biological Activity：NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β.
Research Area：Inflammation/Immunology
Targets：NOD-like Receptor (NLR)|Proteasome
Related Small Molecules:Calpeptin;Calpain Inhibitor VI;MCC950;MG-101;ONX-0914 TFA;MG-115;Dapansutrile;UK-101;SAP2-IN-1;LXE408;NOD-IN-1;GSK3494245;PR-39;NLRP3-IN-4;NLRP3-IN-12;20S Proteasome-IN-1;Nigericin;M3258;PI-1840;Rpn11-IN-1;Delanzomib;Ac-ANW-AMC;Cyclotheonellazole A;Aclacinomycin A;NLRP3-IN-5
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