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Necrosulfonamide

CAS No. : 1360614-48-7

Biological Activity：Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

Research Area：Cancer

Targets：Mixed Lineage Kinase

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Peptidomimetic Library;Covalent Screening Library;Oxygen Sensing Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;

Related Small Molecules:MLKL-IN-1;TC13172;MLKL-IN-2;NecroIr1;MLKL-IN-3;MLK-IN-1;RIP1/RIP3/MLKL activator 1;GW806742X;NecroIr2;URMC-099;MLKL-IN-4;Necrosulfonamide-d4

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