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NecroIr2
Biological Activity：NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression.
Research Area：Cancer
Targets：CDK|Mixed Lineage Kinase|RIP kinase
Related Small Molecules:DB0614;Dinaciclib;SNS-032;CC-671;(E/Z)-Zotiraciclib;RIPA-56;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;RIPK3-IN-2;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;GSK2983559 free acid;FLT3/CDK4-IN-1;GFB-12811;AV123;RIPK1-IN-8;GSK 3 Inhibitor IX;Eciruciclib;CDK-IN-6;RIP2 kinase inhibitor 2;Lerociclib dihydrochloride;CDK4/6-IN-13;ON-013100;RIP2 Kinase Inhibitor 4;(2S,3R)-Voruciclib hydrochloride
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