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MRS4719

CAS No. : 2840581-32-8

Biological Activity：MRS4719 is a potent P2X4 receptor antagonist with an IC₅₀ value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca²⁺]_i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.

Research Area：Neurological Disease

Targets：P2X Receptor

Related Small Molecules:Gefapixant citrate;JNJ-47965567;AF-353;Oxatomide;AZ10606120 dihydrochloride;Taspine;A-317491;NF449 octasodium;A-804598;P2X receptor-1;Aurintricarboxylic acid;Minodronic acid;NF023 hexasodium;A 438079 hydrochloride;KN-62;Opiranserin;GW791343 dihydrochloride;5-BDBD;NF279;Lu AF27139;JNJ-55308942;PPNDS tetrasodium;8-Bromo-ATP;P2X3 antagonist 36;NF110;BAY-1797;Ro-51;P2X3 antagonist 37

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