Mitoxantrone

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Mitoxantrone

CAS No. : 65271-80-9

Biological Activity：Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity[2][3][4]. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].

Research Area：Cancer|Infection

Targets：Topoisomerase|Orthopoxvirus|PKC|Endogenous Metabolite|Apoptosis

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