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Mirk-IN-1

CAS No. : 1386979-55-0

Biological Activity：Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively.
IC50 value: 68±48/22±8 nM (Dyrk1B/Dyrk1A) [1]
Target: Dyrk inhibitor
Mirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by
88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2].

Research Area：Cancer

Targets：DYRK

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;

Related Small Molecules:Harmine hydrochloride;T025;ID-8;Dyrk1A-IN-2;GSK-626616;GNF2133 hydrochloride;ARN25068;Haspin-IN-1;LDN-192960 hydrochloride;CLK-IN-T3;GNF4877;DYRKs-IN-2;JH-XIV-68-3;DYRKs-IN-1 hydrochloride;Protein kinase inhibitors 1 hydrochloride;KH-CB20;Dyrk1A/α-synuclein-IN-2;AZ191;Woodtide;CK2/ERK8-IN-1;DYRK1-IN-1;Dyrk1A-IN-5;ML167;tBID;Dyrk1A-IN-4;Dyrk1A-IN-1

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