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MD-222
CAS No. : 2136246-72-3
Biological Activity：MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects[2].
Research Area：Cancer
Targets：PROTACs|MDM-2/p53|E1/E2/E3 Enzyme
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Oxygen Sensing Compound Library;Ubiquitination Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;UBE2T/FANCL-IN-1;MDM2-p53-IN-15;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;MC-VC-PABC-SP 141;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;p53 and MDM2 proteins-interaction-inhibitor (racemic);MS98;Navtemadlin;JPS014;PROTAC PARP1 degrader;MD-224;FKBP12 PROTAC dTAG-7;DI-1859;SJ10542;MS8815;Mutant p53 modulator-1;MDM2/4-p53-IN-2;RIP2 Kinase Inhibitor 4;MX69;p-nitro-Pifithrin-α;PROTAC EGFR degrader 7;RG7112;SJ995973
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