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M8891
CAS No. : 1464842-09-8
Biological Activity：M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity[2].
Research Area：Cancer|Cardiovascular Disease
Targets：Others
Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Cancer Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Targeted Diversity Library;
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