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LXR antagonist 2
Biological Activity：LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, with IC50 values of 0.36 and 2.25 μM for LXRβ and LXRα, respectively. LXR antagonist 2 is a lipogenesis inhibitor through down-regulating LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 shows lipid-lowering effects in mice with Triton WR-1339-induced hyperlipidemia.
Research Area：Metabolic Disease
Targets：LXR
Related Small Molecules:XL041;BE1218;DMHCA;Saikosaponin A;27-Hydroxycholesterol;LXRβ agonist-3;RGX-104;24(S)-Hydroxycholesterol;SR9238;BMS-779788;SR9243;AZ876;T0901317;LXRβ agonist-2;GSK2033;LXR agonist 1;GW3965;LXR-623;Nagilactone B;LXR agonist 2;Rovazolac;GSK3987
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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