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LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)
Biological Activity：LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier[2].
Research Area：Cancer
Targets：TGF-β Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;TGF-beta/Smad Compound Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Anti-Colorectal Cancer Compound Library ;Peptide Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:ML347;LDN193189 (GMP);TGFβRI-IN-4;ALK5-IN-6;TGFβ-IN-1;p-nitro-Pifithrin-α;Chromenone 1;OD36;ALK5-IN-32;SB-505124 hydrochloride;K02288;ALK5-IN-28;LY-364947;LY3200882;Itacnosertib;J-1063;Maohuoside A;ALK5-IN-27;Galunisertib;ALK2-IN-4 succinate;SB-431542 (GMP);A 83-01;A 77-01;MU1700;Dorsomorphin;ALK5-IN-34;SM 16;SB 525334
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