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LG100268
CAS No. : 153559-76-3
Biological Activity：LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively[2]. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy[3].
Research Area：Metabolic Disease
Targets：Autophagy|RAR/RXR
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Autophagy Compound Library;Pyroptosis Compound Library;Transcription Factor-Targeted Library;Human Metabolite Library;Nuclear Receptor Compound Library;
Related Small Molecules:AGN 193109-d7;Retinoic acid;AC-261066;Magnolol;ER 50891;(+)-Talarozole;Trifarotene;β-Apo-13-carotenone;Bigelovin;CD2665;BMS453;9-cis-Retinoic acid;AGN-195183;Fenretinide;Liarozole dihydrochloride;BMS-195614;LE135;Tamibarotene;UVI 3003;PROTAC RAR Degrader-1;BMS641;Tarenflurbil
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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