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Leukadherin-1
CAS No. : 344897-95-6
Biological Activity:Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling[2][3].
Research Area:Inflammation/Immunology
Targets:Complement System|Integrin
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Cytoskeleton Compound Library;Coagulation and Anti-coagulation Compound Library;
Related Small Molecules:Cemdisiran;Pelecopan;GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl ester sulfate;HSDVHK-NH2;Lifitegrast sodium;TC-I 15;α2β1 Integrin Ligand Peptide;Integrin modulator 1;Veltuzumab;GRGDSP TFA;PMX 205;EG00229;Cyclo(-RGDfK) TFA;Zalunfiban;K34c;Factor B-IN-2;THI0019;RGD;Arg-Gly-Asp-Ser (TFA);Tesidolumab;BIRT 377;Factor B-IN-3;αvβ1 integrin-IN-1
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