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L-006235
CAS No. : 294623-49-7
Biological Activity：L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss[2].
Research Area：Metabolic Disease
Targets：Cathepsin
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Orally Active Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;
Related Small Molecules:Calpeptin;Cathepsin G Inhibitor I;Gly-Phe-β-naphthylamide;Z-FY-CHO;Balicatib;Cathepsin D and E FRET Substrate;N-CBZ-Phe-Arg-AMC TFA;LV-320;Z-LVG-CHN2;ONO-5334;VBY-825;L-873724;Z-WEHD-FMK;Odanacatib;Atg4B-IN-2;Cysteine Protease inhibitor;KGP94;E-64;Cathepsin L-IN-2;LmCPB-IN-1;MK-0674;MIV-247;Aurantiamide acetate;SID 26681509;ALLM;LY 3000328;Cathepsin C-IN-3;Cathepsin C-IN-5;K777
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