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JH-II-127

CAS No. : 1700693-08-8

Biological Activity：JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC₅₀s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson’s syndrome.

Research Area：Neurological Disease

Targets：LRRK2

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;CNS-Penetrant Compound Library;Autophagy Compound Library;Orally Active Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;

Related Small Molecules:LRRK2 inhibitor 1;CZC-25146;LRRK2-IN-2;GNE0877;IKK 16;LRRK2-IN-1;EB-42486;XL01126;PFE-360;GSK2646264;PF-06454589;LRRK2-IN-5;PF-06456384 trihydrochloride;PF-06455943;LRRK2-IN-4;GSK2578215A;LRRK2-IN-6;GNE-9605;GNE-7915;CZC-54252;MLi-2;Indazole;HG-10-102-01;PF-06447475

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