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JB170

CAS No. : 2705844-82-0

Biological Activity：JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC₅₀=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC₅₀=193 nM) over AURORA-B (EC₅₀=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.

Research Area：Cancer

Targets：Aurora Kinase|PROTACs

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Cytoskeleton Compound Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;AT9283;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;MS98;JPS014;PROTAC PARP1 degrader;MD-224;Chiauranib;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;RIP2 Kinase Inhibitor 4;ENMD-2076 Tartrate;PROTAC EGFR degrader 7;SJ995973;Barasertib-HQPA;CC-885-CH2-PEG1-NH-CH3;dFKBP-1;MI-389;BSJ-4-116;AMG 900;SCH-1473759;MS4078;PZ703b

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