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IWP-2
CAS No. : 686770-61-6
Biological Activity：IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ[2].
Research Area：Cancer
Targets：Wnt|Casein Kinase|Porcupine
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Cytoskeleton Compound Library;Neuroprotective Compound Library;Anti-Breast Cancer Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Umbralisib hydrochloride;Wnt/β-catenin agonist 1;ARUK3001185;4,5,6,7-Tetrabromo-1H-benzimidazole;Gallocyanine chloride;Fz7-21;LGK974;TA-01;Foxy-5 TFA;Ellagic acid;CK2 inhibitor 3;Wnt/β-catenin agonist 4;TMCB;JW74;IQ 1;Heparan Sulfate;ETC-159;CK2 inhibitor 2;Laduviglusib (GMP);Longdaysin;D4476;KY-05009;HLY78;Wnt-C59;TTP 22;Wogonin;Orobol;(E/Z)-GO289
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